5 Patents, 50 Human Studies, 40 Review
Articles And 4 Meta-analyses
One of the key ingredients in AgelessLX®, Calcium HMB (calcium β-hydroxy
β-methylbutyrate monohydrate), is a nutritional supplement with over 94 published,
peer-reviewed clinical studies proving its safety and efficacy to:
- Increase strength gains from resistance training
- Decrease muscle discomfort resulting from exercise
- Boost body fat loss and optimize body composition
- Improve recovery after resistance and endurance training
- Reduce muscle protein breakdown
- Maintain lean muscle during calorie restriction
- Boost muscle protein synthesis
Achieve Ideal Weight Loss & Muscle Gains
Typical weight loss strategies reduce both fat and lean body mass, shifting the body into an energy storage mode that can inhibit weight loss progress. HMB is the only ingredient proven to decrease muscle protein breakdown, protecting muscle mass while enhancing fat loss.
Increased percentage body fat loss in older adults:
Vukovich et al. J Nutr 2001
Improved performance outcomes and reduced body fat in athletes during calorie restriction:
Treatment
Body Fat
Muscle Mass
Peak Power
Grip Test
Shuttle Run
Hung et al. J Exerc Sci Fit 2010
Enhanced fat loss and maintained lean body mass during Intermittent Fasting:
Tinsley, AJCN 2019
Strengthen Hair, Skin & Nails
Protect Bone, Joint, Brain & Heart Health
Biotin
Horsetail
Vitamin D3 and Vitamin K2
Biotin is a vitamin in the B family, which helps the body convert food into usable energy for our cells. Research highlights the benefits of biotin for hair, skin, nail, and metabolic health.
- Biotin deficiency has been found in 38% of women with hair loss and is associated with a number of factors, including athleticism, and old age
- 91% of patients with brittle nails showed firmer, harder fingernails with biotin treatment
- Biotin is required for the metabolism of fatty acids, which are essential for skin health
- Nail thickness increased by 25%, splitting decreased, and nail surface became more regular with biotin treatment, in those with brittle nails
- Biotin plays an essential role in maintaining metabolic homeostasis
The trace mineral silicon, in the botanical horsetail, supports the synthesis of collagen in the human body. A growing number of studies are recognizing the importance of optimizing silicon.
- Horsetail extract supplementation increased bone density
- A positive effect on skin uniformity and softness, as well as hair and nail strength occurred with increased silicon concentration
- Silicon promotes bone and connective tissue health
- Silicon in nutritional and supra nutritional amounts promotes bone and connective tissue health, may have a modulating effect on the immune system and has been associated with mental health
- Higher dietary silicon intake in men and younger women may have salutary effects on skeletal health, especially cortical bone health
- A positive relationship has been identified between dietary silicon intake and bone regeneration
- Soluble silica has a dual nature in bone metabolism with stimulatory effects on osteoblasts and inhibitory effects on osteoclasts
- Hair strands with higher silicon content have lower falling rate and higher brightness
Vitamins D3 and K2 are essential, fat soluble nutrients. They work together in the body to regulate calcium balance and have numerous functions that protect our bodies and minds as we age.
- Together, optimal concentrations of vitamin D and K support bone and cardiovascular health
- Vitamin D supports the innate and adaptive immune system responses
- Cell replication and matrix protein synthesis are modulated by vitamin D
- Vitamin K intake is associated with better cognition among older adults
Unzip To See Powerful Science Behind AgelessLX
- Flakoll P, Sharp R, et al. Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women. Nutrition. 2004 May;20(5):445-51.
- Stout J, Smith-Ryan A, et al. Effect of calcium β-hydroxy-β-methylbutyrate (CaHMB) with and without resistance training in men and women 65+yrs: a randomized, double-blind pilot trial. Exp Gerontol. 2013 Nov;48(11):1303-10.
- Wu H, Xia Y, et al. Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults: a systematic review and meta-analysis. Arch Gerontol Geriatr. Sep-Oct 2015;61(2):168-75.
- Wilkinson J, Hossain T, et al. Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism. Clin Nutr. 2018 Dec;37(6 Pt A):2068-2075.
- Wilkinson J, Hossain T, et al. Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. J Physiol. 2013 Jun 1; 591(Pt 11): 2911–2923.Published online 2013 Apr 3.
- Berton L, Bano G, et al. Effect of Oral Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Physical Performance in Healthy Old Women Over 65 Years: An Open Label Randomized Controlled Trial. Published: November 3, 2015.
- Deutz N, Pereira S, et al. Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults. Clin Nutr. 2013 Oct;32(5):704-12.
- Baier S, Johannsen D, et al. Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine. JPEN J Parenter Enteral Nutr. Jan-Feb 2009;33(1):71-82.
- Park B, Henning P, et al. HMB attenuates muscle loss during sustained energy deficit induced by calorie restriction and endurance exercise. Metabolism. 2013 Dec;62(12):1718-29.
- Cheng W, Phillips B, et al. Effect of HMB on fuel utilization, membrane stability and creatine kinase content of cultured muscle cells. FASEB Journal, 12(5), A950.
- Tinsley G, Moore M, et al. Time-restricted feeding plus resistance training in active females: a randomized trial. The American Journal of Clinical Nutrition, Volume 110, Issue 3, September 2019, Pages 628–640.
- Hung W, Liu T, et al. EFFECT OF β-HYDROXY-β-METHYLBUTYRATE SUPPLEMENTATIONDURING ENERGY RESTRICTION IN FEMALE JUDO ATHLETES. Journal of exercise science and fitness (JESF) 8(1):50-53 · June 2010.
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- Park B, Henning P, et al. HMB attenuates muscle loss during sustained energy deficit induced by calorie restriction and endurance exercise. Metabolism. 2013 Dec;62(12):1718-29.
- Lamboley C, Royer D, et al. Effects of beta-hydroxy-beta-methylbutyrate on aerobic-performance components and body composition in college students. Int J Sport Nutr Exerc Metab. 2007 Feb;17(1):56-69.
- Vukovich M, Dreifort G. Effect of beta-hydroxy beta-methylbutyrate on the onset of blood lactate accumulation and V(O)(2) peak in endurance-trained cyclists. J Strength Cond Res. 2001 Nov;15(4):491-7.
- Wilson J, Lowery R, et al. The effects of 12 weeks of beta‑hydroxy‑beta‑methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance‑trained individuals: a randomized, double‑blind, placebo‑controlled study. Eur J Appl Physiol (2014) 114:1217–1227.
- Kuhls D, Rathmacher J, et al. Beta-hydroxy-beta-methylbutyrate supplementation in critically ill trauma patients. J Trauma. 2007 Jan;62(1):125-31; discussion 131-2.
- Knitter A, Panto L, et al. Effects of beta-hydroxy-beta-methylbutyrate on muscle damage after a prolonged run. J Appl Physiol (1985). 2000 Oct;89(4):1340-4.
- Jówko E, Ostaszewski P, et al. Creatine and beta-hydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program. Nutrition. Jul-Aug 2001;17(7-8):558-66.
- Wilson J, Lowery R, et al. β-Hydroxy-β-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men. Br J Nutr. 2013 Aug 28;110(3):538-44.
- Wilson J, Lowery R, et al. The effects of 12 weeks of beta‑hydroxy‑beta‑methylbutyratefree acid supplementation on muscle mass, strength, and power in resistance‑trained individuals: a randomized, double‑blind, placebo‑controlled study. Eur J Appl Physiol (2014) 114:1217–1227.
- Lamboley C, Royer D, et al. Effects of beta-hydroxy-beta-methylbutyrate on aerobic-performance components and body composition in college students. Int J Sport Nutr Exerc Metab. 2007 Feb;17(1):56-69.
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- Nielsen F. Update on the possible nutritional importance of silicon. J Trace Elem Med Biol. 2014 Oct;28(4):379-82.
- Jugdaohsingh R, Tucker K, et al. Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort. J Bone Miner Res. 2004 Feb;19(2):297-307.
- Rodella L, Bonazza V, et al. A review of the effects of dietary silicon intake on bone homeostasis and regeneration. J Nutr Health Aging. 2014 Nov;18(9):820-6.
- Mladenović Z, Johansson A, et al. Soluble silica inhibits osteoclast formation and bone resorption in vitro. Acta Biomater. 2014 Jan;10(1):406-18.
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- Ballegooijen A, Pilz S, et al. The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative
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- Chouet J,1 Guylaine Ferland G, et al. Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study. Nutrients. 2015 Aug; 7(8): 6739–6750.